Polynucleotides Overview
Stimulate Deep Skin Regeneration and Revitalization with Advanced PN Injectables
Duration
30-60 Mins
Sessions
Series Recommended
Downtime
Minimal (Bumps/Bruising)
Key Benefits
- Stimulates natural collagen & elastin
- Improves skin hydration & elasticity
- Enhances overall skin quality & texture
- Reduces fine lines and wrinkles
- Brightens and rejuvenates under-eye area
- Acts as a potent antioxidant
- Natural biostimulation
Common Target Areas
Biostimulation for Healthier Skin
Polynucleotides (PN/PDRN) represent a cutting-edge category of injectable treatments designed to stimulate your skin's natural regenerative processes at a cellular level. Unlike fillers that add volume, polynucleotides act as powerful biostimulators, improving skin quality, hydration, and elasticity from within.
At PRP London Clinic, our medical team offers a range of leading polynucleotide products (including Nucleofill, Plinest, Vitaran, Lumi Eyes) tailored for specific concerns, primarily focusing on Skin Rejuvenation (face/neck) and delicate Under-Eye Treatment. This page provides an overview of this exciting technology.
What Are Polynucleotides (PN/PDRN)?
Polynucleotides are highly purified fragments of DNA extracted typically from salmon or trout DNA (using only the DNA fragments, not cellular material, ensuring high purity and safety). These fragments have unique biological properties when introduced into the skin:
- They act as signalling molecules, stimulating skin cells (fibroblasts) to regenerate.
- They have potent hydrating properties, binding water molecules in the skin.
- They possess antioxidant effects, protecting skin from free radical damage.
- They help create an optimal environment for tissue repair and health.
Essentially, they 'wake up' your skin cells and provide them with the building blocks and signals needed to function more youthfully.
Mechanism of Action: Cellular Regeneration
When injected by our medical team into the skin, polynucleotides trigger a cascade of beneficial effects:
- Fibroblast Stimulation: They directly encourage fibroblasts to produce more collagen and elastin, improving skin firmness and elasticity over time.
- Deep Hydration: Their hydrophilic nature attracts water, leading to improved skin hydration and plumpness.
- Antioxidant & Anti-Inflammatory: They help protect skin from damaging free radicals and reduce subtle inflammation associated with ageing.
- Tissue Repair: They support the skin's natural repair mechanisms, improving overall skin health and quality.
Unlike immediate volumising fillers, polynucleotides work biologically over weeks and months to improve the fundamental health and structure of the skin.
Key Treatment Areas
Polynucleotide treatments offered by our medical team are particularly effective for:
Under-Eye Rejuvenation
Targeting dark circles, fine lines, and crepey skin in the delicate under-eye area using specialised products like Nucleofill Eyes, Plinest Eyes, Vitaran Eyes, or Lumi Eyes.
Skin Rejuvenation (Face, Neck, Décolletage)
Improving overall skin quality, hydration, elasticity, fine lines, and texture using products like Nucleofill Skin, Plinest Skin, or Vitaran Skin.
Polynucleotide Brands We Use
Our medical team uses leading, CE-marked polynucleotide brands known for their specific formulations and efficacy:
- Nucleofill: Offers specific formulations for Soft Plus (Eyes/Skin) and Medium/Strong (Skin).
- Plinest / Plinest Eye: High-concentration PN products for skin and delicate eye areas.
- Vitaran: PN product effective for both under-eye (Vitaran I) and general skin hydration/quality.
- Lumi Eyes: Specifically formulated PN product targeting under-eye concerns.
The choice of brand and product depends on the treatment area and your specific skin goals, discussed during consultation.
The Polynucleotide Injection Procedure
Treatment involves a consultation with our medical team, skin cleansing, and application of topical numbing cream. The polynucleotide product is then administered via a series of small injections using either very fine needles or sometimes a cannula, depending on the area and technique chosen (e.g., multiple micro-boluses across the face or targeted injections under the eyes). The procedure typically takes 30-60 minutes. Small bumps at the injection sites are common immediately after but usually settle within hours to a day or two.
Results Timeline & Longevity
Polynucleotides work by stimulating your skin's own processes, so results are gradual:
- Initial Hydration Boost: Often noticed within the first few weeks.
- Improved Skin Quality: Texture, elasticity, and fine lines typically show improvement over 2-3 months as collagen production increases.
- Peak Results: Usually seen after completing the recommended course of treatments.
A course of 2-4 sessions, spaced 2-4 weeks apart, is generally recommended for optimal results. Maintenance sessions every 6-9 months can help sustain the benefits.
Safety of Polynucleotide Treatments
Polynucleotide injections have a high safety profile. The products are highly purified DNA fragments, minimising risks of allergic reactions. Common side effects are related to the injections themselves: temporary redness, swelling, small bumps (which resolve quickly), or bruising at the injection sites. Serious complications are rare when administered by our trained medical professionals.
Advanced Polynucleotide Treatments in London
Experience the regenerative power of polynucleotides at PRP London Clinic. Consult with our medical team for tailored skin and under-eye solutions.
Invest in Your Skin's Long-Term Health
Discover how biostimulation with Polynucleotides can naturally rejuvenate your skin. Book your a consultation with our medical team at PRP London Clinic today.
Myths vs Facts
Polynucleotides are just another type of filler.
False. Fillers add immediate volume. Polynucleotides are biostimulators that improve skin quality and structure over time by stimulating your own cells.
Polynucleotide results are instant.
No, they work biologically. Initial hydration may be seen early, but collagen stimulation and significant skin quality changes take weeks to months.
They are made from unsafe fish parts.
The DNA fragments are highly purified and processed in labs under strict sterile conditions, removing allergenic proteins. They are considered very safe.
One session is enough for full results.
A course of 2-4 sessions is typically required to build up the biological stimulation needed for optimal, lasting results.
Polynucleotides Cost
| Treatment | Price |
|---|---|
| Under Eyes Per session. Polynucleotide treatment for under eye rejuvenation. | £325per treatment |
| Face Per session. Polynucleotide treatment for facial rejuvenation. | £325per treatment |
| Neck Per session. Polynucleotide treatment for neck rejuvenation. | £325per treatment |
| Décolletage Per session. Polynucleotide treatment for décolletage rejuvenation. | £325per treatment |
Prices are indicative. Please book a consultation for a personalised quote.
Frequently Asked Questions
Quick Links
Our Medical Team
Your treatment will be performed by one of our qualified medical professionals
Dr Mohammad Akbar
GMC-Registered
FRCS (Edinburgh) Fellow of the Royal College of Surgeons with extensive experien...
Dr Mohamed Nafei
GMC-Registered
GMC-registered doctor with 10+ years experience. Expert in PRP, exosomes, and ad...
Profile
Dr Severine Leonet
GMC-Registered
GMC-registered doctor with over 8 years in medical aesthetics. Expert in injecta...
Profile
Dr Reem Nouri
GMC-Registered
GMC-registered doctor with nearly 20 years of medical experience including 10+ y...
ProfileScroll to see all
Ready to Get Started?
Book your consultation today and take the first step towards your transformation.
What Our Patients Are Saying
Hear from our satisfied patients about their experience with at our clinics.