Polynucleotide Injections London

Polynucleotide injections represent a breakthrough in skin rejuvenation—a powerful biostimulator that goes beyond traditional skin boosters. Unlike hyaluronic acid treatments that primarily hydrate, polynucleotides (PN) and related DNA-fragment technologies are proposed to support cellular signalling and dermal repair pathways associated with tissue regeneration.

At PRP London Clinic, our GMC-registered medical team uses CE-marked polynucleotide products including VITARAN II, Nucleofill, and PolyPhil™ to rejuvenate the face, neck, décolletage, and hands. For targeted under-eye concerns, see our dedicated Polynucleotide Under Eye Treatment page.

Our polynucleotide skin booster results demonstrate visible improvements in skin texture, fine lines, hydration, and overall radiance. These before and after images show real patients treated at PRP London Clinic.

Polynucleotides (PN) are highly purified fragments of DNA extracted from salmon or trout (using only the DNA fragments, not cellular material, ensuring high purity and safety). These fragments are proposed to have beneficial biological properties when introduced into the skin:

• Cellular Signalling: Suggested mechanisms include acting as signalling molecules, proposed to support fibroblast activity and collagen production.
• Deep Hydration: They are proposed to have hydrating properties, helping to retain moisture in the skin.
• Antioxidant Protection: Preclinical and limited human data indicate potential antioxidant effects.
• Tissue Repair: They are proposed to support the skin's natural repair mechanisms and cellular health.

Polynucleotides are thought to support cellular signalling and dermal repair pathways associated with tissue regeneration. While these mechanisms are supported by preclinical and limited clinical data, the precise molecular pathways of polynucleotides in human skin are not yet fully established.

When injected into the dermal layers by our medical team, polynucleotides are proposed to initiate beneficial biological effects. Suggested mechanisms include:

• Fibroblast Support: Proposed to support fibroblast activity and promote production of collagen, elastin, and hyaluronic acid.
• Deep Hydration: Their hydrophilic molecular structure is thought to attract and retain water in the skin.
• Antioxidant & Anti-Inflammatory: Preclinical data indicate potential free radical scavenging and anti-inflammatory effects.
• Improved Microcirculation: Some studies suggest enhanced blood flow, potentially bringing more nutrients and oxygen to skin cells.
• Tissue Repair: Proposed to support the skin's natural repair mechanisms and cellular health.

Unlike immediate volumising fillers, polynucleotides work biologically over weeks and months. While these mechanisms are supported by preclinical and limited clinical data, the precise molecular pathways in human skin are not yet fully established.

Both polynucleotides and Profhilo® are popular skin boosters, but they work differently:

Some comparative studies report differences in cellular activity compared with hyaluronic acid; however, results vary by formulation and study design. Many patients benefit from combining both treatments. Our medical team can advise which approach suits your skin.

Our Clinical Board selects from leading CE-marked polynucleotide products specifically suited for face, neck, and body rejuvenation:

• VITARAN II: High-concentration 20mg/ml PN from BR Pharm, specifically formulated for face, neck, hands, and body laxity. Derived from purified Salmon Trout DNA.
• Nucleofill Medium/Strong: A Class III CE-marked bio-restructuring gel from Promoitalia offering significant biostimulation and liquid lifting effects for facial and neck skin.
• PolyPhil™ (PN-HPT®): High Purification Polynucleotides from Croma-Pharma using patented PN-HPT® technology for deep skin biorevitalisation and elasticity improvement.

The best product for you will be selected based on your skin concerns and treatment goals during consultation.

Our medical team follows a precise clinical protocol for polynucleotide face and neck treatment.

Treatment involves a consultation with our medical team, skin cleansing, and application of topical numbing cream for 20-30 minutes. The polynucleotide product is then administered via a series of small injections (micro-boluses) using fine 30G needles, strategically placed across the face, neck, or other target areas. The injection technique ensures even distribution for widespread biostimulation. The procedure typically takes 30-60 minutes depending on the area(s) treated. Small bumps at the injection sites are common immediately after but usually settle within 24-48 hours.

Polynucleotides are proposed to work by supporting your skin's regenerative processes, so results are gradual:

• Weeks 1-4: Many patients report enhanced hydration, subtle glow, and improved skin feel as initial effects begin.
• Months 1-3: Many patients report improvements in skin elasticity, texture, fine lines, and overall radiance.
• Optimal Results: Usually reported after completing the recommended course of 2-4 treatments.

Clinical outcomes vary based on age, skin condition, and individual regenerative response. Treatments are typically spaced 2-4 weeks apart. Maintenance sessions every 6-9 months may help sustain the skin health benefits.

Polynucleotide injections are effective across multiple treatment areas:

• Full Face: Overall skin rejuvenation, improving texture, hydration, fine lines, and radiance.
• Neck: Addressing crepey skin, loss of elasticity, and horizontal neck lines.
• Décolletage: Improving sun-damaged, thin, or ageing skin on the chest area.
• Hands: Rejuvenating ageing hands with improved skin quality and hydration.
• Under Eyes: For dedicated periorbital treatment, see our Polynucleotide Under Eye page.

Polynucleotide treatment is priced per session and per area. See the pricing table below for current costs. A course of 2-4 sessions is typically recommended for optimal biostimulation results.

Published clinical studies generally report good tolerability with predominantly mild, self-limiting side effects; however, as with all injectable medical procedures, risks cannot be completely eliminated.

Common temporary side effects:

• Small bumps (blebs) at injection sites—resolve within 24-48 hours
• Mild redness and swelling—resolves within 1-3 days
• Potential bruising—resolves within 5-10 days
• Slight tenderness at injection sites

Contraindications: Although allergenic proteins are removed during purification, patients with known fish or seafood allergies are treated as a precautionary contraindication. Other contraindications include autoimmune diseases, pregnancy or breastfeeding, and active skin infections.

Serious complications are rare when administered by our trained medical professionals using CE-marked products that meet regulatory safety standards.

Polynucleotide therapy is a medical procedure. Individual results vary based on age, skin condition, lifestyle factors, and individual biological response. CE-marked PN products meet regulatory compliance and safety standards, but this does not guarantee specific clinical outcomes. Results depend on individual regenerative capacity. A professional consultation with our GMC-registered medical team is required to determine suitability and set realistic expectations.

Evidence Note: Most published studies on polynucleotides are small or observational, with heterogeneity in products, protocols, and outcomes. More high-quality randomised controlled trials are required to definitively establish efficacy. These references are provided for educational purposes and do not replace individual clinical assessment.

Experience advanced polynucleotide injections at PRP London Clinic in Harley Street and across our London locations. Our GMC-registered doctors specialise in skin rejuvenation using CE-marked VITARAN II, Nucleofill, and PolyPhil products for face, neck, and décolletage.

Discover how biostimulation with polynucleotides can naturally regenerate your skin. Book a consultation with our medical team at PRP London Clinic today to discuss your treatment goals.