Polynucleotides Overview

Polynucleotides (PN/PDRN) represent a cutting-edge category of injectable treatments designed to stimulate your skin's natural regenerative processes at a cellular level. Unlike fillers that add volume, polynucleotides act as powerful biostimulators, improving skin quality, hydration, and elasticity from within.

At PRP London Clinic, Dr. Hans offers a range of leading polynucleotide products (including Nucleofill, Plinest, Vitaran, Lumi Eyes) tailored for specific concerns, primarily focusing on Skin Rejuvenation (face/neck) and delicate Under-Eye Treatment. This page provides an overview of this exciting technology.

Polynucleotides are highly purified fragments of DNA extracted typically from salmon or trout DNA (using only the DNA fragments, not cellular material, ensuring high purity and safety). These fragments have unique biological properties when introduced into the skin:

• They act as signalling molecules, stimulating skin cells (fibroblasts) to regenerate.
• They have potent hydrating properties, binding water molecules in the skin.
• They possess antioxidant effects, protecting skin from free radical damage.
• They help create an optimal environment for tissue repair and health.

Essentially, they 'wake up' your skin cells and provide them with the building blocks and signals needed to function more youthfully.

When injected by Dr. Hans into the skin, polynucleotides trigger a cascade of beneficial effects:

• Fibroblast Stimulation: They directly encourage fibroblasts to produce more collagen and elastin, improving skin firmness and elasticity over time.
• Deep Hydration: Their hydrophilic nature attracts water, leading to improved skin hydration and plumpness.
• Antioxidant & Anti-Inflammatory: They help protect skin from damaging free radicals and reduce subtle inflammation associated with ageing.
• Tissue Repair: They support the skin's natural repair mechanisms, improving overall skin health and quality.

Unlike immediate volumising fillers, polynucleotides work biologically over weeks and months to improve the fundamental health and structure of the skin.

Polynucleotide treatments offered by Dr. Hans are particularly effective for:

Dr. Hans utilizes leading, CE-marked polynucleotide brands known for their specific formulations and efficacy:

• Nucleofill: Offers specific formulations for Soft Plus (Eyes/Skin) and Medium/Strong (Skin).
• Plinest / Plinest Eye: High-concentration PN products for skin and delicate eye areas.
• Vitaran: PN product effective for both under-eye (Vitaran I) and general skin hydration/quality.
• Lumi Eyes: Specifically formulated PN product targeting under-eye concerns.

The choice of brand and product depends on the treatment area and your specific skin goals, discussed during consultation.

Treatment involves a consultation with Dr. Hans, skin cleansing, and application of topical numbing cream. The polynucleotide product is then administered via a series of small injections using either very fine needles or sometimes a cannula, depending on the area and technique chosen (e.g., multiple micro-boluses across the face or targeted injections under the eyes). The procedure typically takes 30-60 minutes. Small bumps at the injection sites are common immediately after but usually settle within hours to a day or two.

Polynucleotides work by stimulating your skin's own processes, so results are gradual:

• Initial Hydration Boost: Often noticed within the first few weeks.
• Improved Skin Quality: Texture, elasticity, and fine lines typically show improvement over 2-3 months as collagen production increases.
• Peak Results: Usually seen after completing the recommended course of treatments.

A course of 2-4 sessions, spaced 2-4 weeks apart, is generally recommended for optimal results. Maintenance sessions every 6-9 months can help sustain the benefits.

Polynucleotide injections have a high safety profile. The products are highly purified DNA fragments, minimizing risks of allergic reactions. Common side effects are related to the injections themselves: temporary redness, swelling, small bumps (which resolve quickly), or bruising at the injection sites. Serious complications are rare when administered by a trained medical professional like Dr. Hans.

Experience the regenerative power of polynucleotides at PRP London Clinic. Consult with Dr. Hans for tailored skin and under-eye solutions.

Discover how biostimulation with Polynucleotides can naturally rejuvenate your skin. Book your consultation with Dr. Hans at PRP London Clinic today.