PRF Biofiller London (EZ Gel / Alb-PRF)

PRF Biofiller is an autologous plasma gel treatment, and EZ Gel is an Alb-PRF technique used to create this biofiller from your own blood. At PRP London Clinic, we offer PRF Biofiller using the EZ Gel method as part of our regenerative PRF London approach—the gold standard in autologous facial rejuvenation. Our EZ Gel technique uses the regenerative power of your own blood to create a 100% natural, biocompatible filler. This cutting-edge treatment delivers subtle yet effective results for hollow cheeks, sunken temples, under-eye dark circles, and fine lines, stimulating collagen production for lasting improvements.

If you're searching for PRF Biofiller near me or EZ Gel London, we are conveniently based in central London with GMC-registered practitioners. For a deeper diagnostic look at the causes of under-eye concerns, read our clinical guide on Hollow Under-Eyes and Dark Circles.

No. Many 'plasma gel' treatments use heated Platelet-Poor Plasma (PPP), which primarily provides short-term volume with limited regenerative signalling. EZ Gel, when prepared as Alb-PRF, combines an albumin scaffold with PRF biology to support tissue quality improvements over time.

Our EZ Gel results demonstrate significant correction of Type 1-3 Tear Trough Deformity, with visible improvement in under-eye hollowing, dark circles, and mid-face volume loss. In our central London clinic, we achieve high patient satisfaction for volume restoration in the mid-face and under-eye regions.

The PRF London protocol utilises Extended Platelet-Rich Fibrin (e-PRF), clinically categorised as Alb-PRF. Unlike standard PRP, which has a short biological window, Alb-PRF creates a heat-coagulated albumin scaffold. This allows for sustained TGF-β activity and growth factor release over 10–14 days (Biological characterization of Alb-PRF, PubMed 31959025), driving superior dermal thickening and structural rejuvenation.

Our practitioners subject your plasma to a precision-controlled Thermal Induction curve. This specific technique denatures the albumin, creating a stable 3D bio-scaffolding that encapsulates your body's growth factors—extending the regenerative window far beyond conventional treatments.

The foundations of the Alb-PRF we use today were established in the early 2000s in the field of dental and maxillofacial surgery (Choukroun et al.). While many clinics treat 'Biofiller' as a new aesthetic trend, our Clinical Board views it through its original regenerative intent: providing a stable, fibrin-rich scaffold for tissue repair.

This surgical-grade background ensures that every treatment at PRP London Clinic is performed with the highest understanding of biological cell response. While basic 'Plasma Gels' emerged in 2016 using simple heated Platelet-Poor Plasma (PPP), they lacked regenerative activity. The PRF London Protocol utilises the most advanced iteration (2020–Present):

• Phase 1 (Choukroun et al.): PRF established the biological basis for autologous healing in dentistry and oral surgery.
• Phase 2 (i-PRF): Enabled injectable regeneration but provided minimal volumetric effect.
• Phase 3 (The Alb-PRF Breakthrough): By combining heat-induced albumin 'scaffolding' with liquid PRF, we created a 100% natural filler that possesses both mechanical volume and high biological activity.

At PRP London Clinic, our EZ Gel technique is an advanced bio-refining process where we transform your own plasma into a stable, regenerative filler. Utilising medical-grade T-Lab™ technology as our baseline, our specialists isolate Platelet-Rich Fibrin (PRF) and albumin proteins from a small sample of your blood.

Through a clinic-controlled process of thermal induction, we denature these proteins to create a 100% natural, smooth gel. This PRF London signature approach offers a biocompatible alternative to synthetic fillers, designed not just to mask hollows, but to stimulate long-term collagen and elastin production within your skin's own architecture.

The 'No-Treatment' Rule: Our Commitment to Results

At PRP London Clinic, our Clinical Board follows a strict integrity filter. We will not recommend EZ Gel Biofiller if your anatomy suggests a poor clinical outcome. As an autologous treatment, success depends on your own biological regenerative capacity and correct anatomical indication.

Who is an Ideal Candidate?

• Tear Trough Grade 1-3: Patients with mild to moderate hollows caused by fat pad loss.
• Vascular Dark Circles: Individuals with thin, translucent skin where underlying vessels create a blue/purple shadow.
• Mid-Face Lipoatrophy: Patients experiencing a 'gaunt' appearance due to subcutaneous fat loss.
• The 'Natural-First' Patient: Individuals seeking a 100% chemical-free (BDDE-free) alternative to synthetic fillers.

Who is NOT a Candidate? (The 'No' Filter)

• Malar Edema & Festoons: If you suffer from chronic puffiness or fluid retention under the eyes, any injectable—including EZ Gel—can worsen the appearance of 'bags' by attracting more fluid.
• Severe Fat Prolapse: If your concerns are caused by protruding fat pads (true eye bags) rather than a hollow, surgical blepharoplasty is the only clinically indicated solution.
• Advanced Skin Laxity: For severe 'crepey' skin or drooping lids, non-surgical fillers cannot replace the structural results of surgery.
• Platelet Dysfunction: As we utilize the T-Lab™ PRF system, patients with low platelet counts or active blood disorders will not see the required biological response.

• Under-eye hollows and dark circles (tear troughs) – our primary indication and ideal for those seeking PRF under eyes London treatments
• Fine lines, wrinkles, and crepey skin texture
• Correction of mid-face hollowing and restoration of subcutaneous fat pad volume (softening of gaunt appearance)
• Temple hollowing and volume loss
• Nasolabial folds (smile lines)
• Marionette lines
• Jawline definition and enhancement
• Overall skin texture and radiance improvement
• Acne scars (in some cases, by improving skin structure)

Every EZ Gel procedure follows the PRP London Clinic Diagnostic Framework, ensuring the treatment is tailored to your unique facial vectors.

1. Precision Phlebotomy: We perform vacuum-sealed collection using 21G phlebotomy sets to ensure maximum cell viability.
2. Bio-Isolation: Your blood is processed using our precision-optimised centrifugation protocol at 700–800 G for 8 minutes. We specifically avoid higher RCF settings (such as 1500 RCF) which in our clinical experience cause premature fibrin activation, thread formation in the sample, and nodule formation upon injection. Our low-G protocol ensures a smooth, stable gel consistency with optimal platelet viability.
3. Matrix Creation: We execute our proprietary heating and cooling cycle to turn the liquid plasma into a stable Bio-matrix.
4. Vector Mapping: Our doctors map the 'Vector of Volume Loss' in the face to identify the precise injection paths.
5. Cannula Mastery: Utilising blunt-tipped micro-cannulas, we layer the EZ Gel into the target tissues. This technique ensures a natural, smooth transition and protects the delicate vascular network of the eye.

• 100% Natural & Autologous: Uses your body's own materials, minimising risk of allergic reactions or rejection.
• Dual Action: Provides immediate subtle volumisation and stimulates long-term collagen production for progressive, natural-looking results.
• Versatile: Effectively treats a wide range of facial areas and concerns.
• Improved Skin Quality: Enhances skin texture, firmness, and radiance due to growth factor stimulation.
• Safe Alternative: An excellent option for those seeking a more holistic approach compared to synthetic fillers, including PRF EZ Gel London patients.
• Minimally Invasive: A non-surgical treatment with minimal downtime.

• GMC-Led Oversight: Our Clinical Board, overseen by our Medical Director, ensures that every regenerative protocol meets the highest UK safety standards.
• Technique over Product: We don't just provide EZ Gel; we provide a specialised injection technique focused on anatomical restoration and dermal health.
• Advanced Hardware Selection: Our board specifically selected the T-Lab™ system and developed bespoke spin protocols to prevent immature fibrin activation, ensuring a smooth, biocompatible integration into the facial tissues.
• Safety-First Philosophy: By prioritising micro-cannula techniques and diagnostic mapping, we provide a safer, more medically-sound path to facial rejuvenation.

Following your PRF Biofiller / EZ Gel treatment, you might experience mild swelling, redness, or bruising at the injection sites, which typically subsides within a few days to a week. Most patients can resume normal activities immediately or shortly after. As a leading provider of PRF London services, our clinic ensures every treatment meets the highest standards. Our medical team will provide comprehensive aftercare instructions, which may include avoiding strenuous exercise, excessive heat, and certain medications for a short period to ensure optimal healing and results. This treatment is considered very safe due to its autologous nature.

Note: As with all medical and regenerative treatments, results from PRF Biofiller and EZ Gel vary between individuals. Factors such as age, lifestyle, anatomical structure, and biological response to autologous growth factors significantly influence the outcome.

All treatments at PRP London Clinic are subject to a mandatory clinical assessment by our GMC-registered board to determine medical suitability. PRF treatments utilise the T-Lab™ Class IIB medical system; however, individual regenerative capacity is unique to each patient. Information provided on this page is for educational purposes and does not constitute a guaranteed result or replace a formal medical consultation. Risks, including localised swelling or bruising, will be discussed in detail during your diagnostic appointment.