Polynucleotide Under Eye Injections

The under-eye area is often one of the first places to show signs of ageing, including dark circles, fine lines, and thin, crepey skin. Polynucleotide (PN) injections offer a powerful regenerative solution specifically designed for this delicate periorbital zone. Unlike fillers that primarily add volume, PN treatments work biologically to improve skin health and quality from within.

At PRP London Clinic, our GMC-registered medical team uses CE-marked polynucleotide products including Vitaran Eyes, Nucleofill Soft Plus, and PolyPhil™ to target under-eye concerns effectively. Learn more about the benefits of Polynucleotide Injections for the full face and neck, or see our guide on Under-Eye Hollowing.

Our polynucleotide under eye results demonstrate significant improvements in dark circles, skin texture, and fine lines. These before and after images show real patients treated at PRP London Clinic using CE-marked PN products.

When injected into the tear trough and surrounding under-eye skin, polynucleotides are proposed to provide biological benefits. Suggested mechanisms include:

• Improved Skin Quality: Proposed to support fibroblast activity and collagen/elastin production, potentially thickening the skin and reducing the appearance of fine lines.
• Deep Hydration: PN molecules are hydrophilic, proposed to attract moisture and hydrate the thin under-eye skin.
• Reduced Dark Circles: By potentially improving skin thickness, PN may lessen the appearance of dark circles caused by thin skin revealing underlying vessels.
• Antioxidant Protection: Preclinical data suggest potential antioxidant effects for the delicate periorbital skin.
• Tissue Repair: Proposed to support the skin's natural repair mechanisms and cellular health.

While these mechanisms are supported by preclinical and limited clinical data, the precise molecular pathways in human skin are not yet fully established.

Our Clinical Board selects from leading CE-marked products specifically formulated for the delicate periorbital area:

• Vitaran Eyes: High-concentration 20mg/ml PN from BR Pharm, CE-marked and specifically designed for peri-orbital hollows and fine lines. Derived from purified Salmon Trout DNA.
• Nucleofill Soft Plus: A Class III CE-marked bio-restructuring gel from Promoitalia, composed of long-chain salmon-derived polynucleotides for tissue regeneration and antioxidant protection.
• PolyPhil™ (PN-HPT®): High Purification Polynucleotides from Croma-Pharma using patented PN-HPT® technology derived from Trout DNA, indicated for periorbital rejuvenation.

The choice depends on your specific concerns and our medical team's assessment during consultation.

Our medical team follows a precise clinical protocol to ensure optimal results and patient safety for polynucleotide under eye treatment.

Following consultation and cleansing, topical numbing cream is applied to the under-eye area for 20-30 minutes. Our practitioner then uses either a very fine needle or a cannula technique to administer multiple small injections of the chosen polynucleotide product into the superficial layers of the skin around and under the eye. The procedure typically takes 30-45 minutes. Small bumps under the skin immediately after injection are common and expected, usually resolving within 1-2 days.

Improvements are gradual as polynucleotides are proposed to support cellular activity:

• Weeks 1-4: Many patients report initial improvement in hydration and skin brightness. Any initial swelling or bumps resolve.
• Months 1-3: Many patients report reduction in fine lines, improved skin texture and elasticity, and lightening of dark circles.
• Optimal Results: Best results are typically reported after completing the recommended course of 2-4 sessions.

Clinical outcomes vary based on age, skin condition, and individual regenerative response. Treatments are usually spaced 2-4 weeks apart. Maintenance sessions every 6-9 months may help preserve the results.

While both treat the under-eye area, they work differently and address different concerns:

They can sometimes be used complementarily—PN for skin support, HA for structural volume. Our medical team will advise which is more suitable for your specific concerns.

Polynucleotide under eye treatment is £325 per session. A course of 2-4 sessions is typically recommended for optimal results.

Considering treating face & neck too? View our full Polynucleotide Treatment page for complete pricing and combination packages.

Published clinical studies generally report good tolerability with predominantly mild, self-limiting side effects when performed by experienced practitioners; however, as with all injectable medical procedures, risks cannot be completely eliminated.

Common side effects (temporary):

• Small bumps (blebs) at injection sites—resolve within 24-48 hours
• Mild redness and swelling—resolves within 1-3 days
• Potential bruising—resolves within 5-10 days
• Slight tenderness

Contraindications: Although allergenic proteins are removed during purification, patients with known fish or seafood allergies are treated as a precautionary contraindication. Other contraindications include autoimmune diseases, pregnancy or breastfeeding, and active skin infections.

Polynucleotide therapy is a medical procedure. Individual results vary based on age, skin condition, lifestyle factors, and individual biological response. CE-marked PN products meet regulatory compliance and safety standards, but this does not guarantee specific clinical outcomes. Results depend on individual regenerative capacity. A professional consultation with our GMC-registered medical team is required to determine suitability and set realistic expectations.

Evidence Note: Most published studies on polynucleotides are small or observational, with heterogeneity in products, protocols, and outcomes. More high-quality randomised controlled trials are required to definitively establish efficacy. These references are provided for educational purposes and do not replace individual clinical assessment.

Experience advanced polynucleotide under eye injections at PRP London Clinic in Harley Street and across our London locations. Our GMC-registered doctors specialise in periorbital rejuvenation using CE-marked Vitaran, Nucleofill, and PolyPhil products.

Address dark circles, fine lines, and tired-looking eyes with advanced Polynucleotide therapy. Book a consultation with our medical team at PRP London Clinic to see if polynucleotide under eye treatment is right for you.