Sylfirm X RF microneedling device used for melasma and skin rejuvenation treatment at PRP London Clinic, Cavendish Square

Sylfirm X London

The world's first dual-wave RF microneedling — treating melasma, rosacea, and skin ageing with precision at our Cavendish Square clinic.

Duration

45-60m

Sessions

3-5

Price From

£350

Downtime

1-3 Days

Key Benefits

  • World's only dual-wave RF (Pulsed & Continuous)
  • Clinically validated for melasma and refractory pigmentation
  • Selectively treats rosacea-related redness and vascularity
  • Safe for all skin types including darker tones (Fitzpatrick I-VI)
  • Periorbital treatment capability (eyes, lids, crow's feet)
  • Stimulates deep collagen for skin tightening
  • No risk of unwanted facial fat loss
  • Minimal downtime (1-3 days)

Common Target Areas

Full Face Neck Décolletage Eye Area (Periorbital) Abdomen Body Areas Stretch Marks

What is Sylfirm X & How Does It Work?

Sylfirm X is the world's first and only dual-wave radiofrequency microneedling system — a device that has fundamentally changed what RF microneedling can treat. At PRP London Clinic, 33 Cavendish Square, London W1G, our GMC-registered doctors use Sylfirm X London to deliver targeted results for conditions that were previously resistant to energy-based devices, including stubborn melasma, persistent rosacea, and acne scarring.

The dual-wave technology combines two distinct RF modes in a single device:

  • Continuous Wave (CW): Delivers sustained thermal energy to tighten skin, stimulate collagen remodelling, and address fine lines and laxity — comparable to other premium RF microneedling systems.
  • Pulsed Wave (PW): The breakthrough. Short, controlled bursts of energy selectively target abnormal blood vessels and melanocytes without damaging surrounding tissue. This is what makes Sylfirm X treatment uniquely effective for melasma, rosacea-related redness, and vascular conditions where other devices carry unacceptable risk.

For patients researching Sylfirm X UK options, our Cavendish Square clinic offers the combination of genuine certified equipment, doctor-only delivery, and the clinical expertise to calibrate dual-wave settings precisely for each patient's skin type and concern.

This procedure is part of our comprehensive Guide to Jowls & Lower Face Sagging.

Your Sylfirm X Medical Team

Every Sylfirm X London session is performed by a GMC-registered doctor from our clinical team — Dr Bruno Amendola (GMC: 4346629), Dr Mohamed Nafei (GMC: 7520509), and Dr Reem Nouri (GMC: 6149512). Our doctors are trained on both Pulsed Wave and Continuous Wave modalities and follow standardised dual-wave RF protocols developed through shared clinical workflows, ensuring consistent outcomes regardless of which physician performs your procedure. Never a nurse, technician, or non-medical practitioner.

Sylfirm X Before and After: 7 Real Cases

These Sylfirm X before and after results are from real patients treated at our London clinic. They demonstrate the significant improvements in skin tone, texture, scarring, and firmness achievable with a personalised treatment course using dual-wave RF microneedling.

Atrophic Acne Scars

Significant improvement in the appearance of atrophic acne scars through collagen remodelling

BEFORE
AFTER
BeforeAfter
1 of 7

What Sylfirm X Treats: Clinical Applications

Melasma & Stubborn Pigmentation

Sylfirm X melasma treatment is the device's flagship application. The Pulsed Wave mode selectively targets dysfunctional melanocytes and abnormal vasculature in the dermal-epidermal junction — the root cause of refractory melasma — without triggering the inflammatory rebound that makes other energy devices risky for pigmentation. A 2022 split-face randomised controlled trial (PMID: 35538360) demonstrated that pulsed-type noninsulated microneedle RF was safe and effective for melasma improvement in Fitzpatrick skin types III-V.

Rosacea & Vascular Redness

Sylfirm X rosacea treatment uses the Pulsed Wave to selectively coagulate the abnormal, dilated blood vessels responsible for persistent facial redness, flushing, and telangiectasias. Clinical evidence (PMID: 33650938) has demonstrated that pulsed-type bipolar RF produces rapid clinical improvement in facial erythema associated with rosacea, offering a treatment pathway for patients frustrated by the limitations of topical therapies alone.

Skin Tightening & Anti-Ageing

The Continuous Wave mode delivers sustained thermal energy to the deep dermis, stimulating robust neocollagenesis and elastin remodelling. This translates directly into measurable Sylfirm X skin tightening — firmer, more lifted skin on the face, neck, and décolletage. For patients asking is Sylfirm X worth it for ageing concerns, the answer depends on whether their primary goal is skin quality improvement (where Sylfirm X excels) versus deep fat remodelling (where Morpheus8 may be more appropriate).

Acne Scars & Texture

Fractional RF microneedling is supported by strong evidence for Sylfirm X acne scars treatment. A 2025 systematic review of 16 studies (481 patients, PMID: 39781098) confirmed that fractional RF microneedling is an effective monotherapy for atrophic acne scarring, with over 80% of patients achieving a two-grade scar improvement. The controlled micro-injuries combined with RF energy stimulate collagen remodelling in the scar bed.

Periorbital Rejuvenation: Sylfirm X for Eyes

The delicate area around the eyes is one of the first to show ageing — and one of the hardest to treat safely. Sylfirm X for eyes addresses hooded eyelids, crow's feet, under-eye crepiness, and vascular dark circles. Because the device delivers energy at precisely controlled depths, it can safely treat the thin periorbital skin where other RF devices cannot go. Sylfirm X under eye and Sylfirm X eyelids treatments start from £650.

Neck, Body & Stretch Marks

Sylfirm X neck treatment targets crepey skin and horizontal lines using the Continuous Wave mode for collagen tightening. The device is also effective on the décolletage, abdomen, and Sylfirm X stretch marks — remodelling the dermal matrix to improve texture and tone in these harder-to-treat body areas.

Your Sylfirm X Treatment Experience

Every Sylfirm X treatment at our clinic follows a structured clinical protocol designed for comfort, safety, and optimal results:

  1. Personalised Consultation: Your journey begins with an in-depth skin assessment with one of our GMC-registered doctors. We analyse your skin type (Fitzpatrick scale), map your concerns, and design a bespoke treatment plan — including which wave mode (PW, CW, or combination) and how many sessions you will need.
  2. Skin Preparation: On treatment day, your skin is thoroughly cleansed and a strong topical anaesthetic cream is applied for 45-60 minutes to ensure comfort throughout the procedure.
  3. Dual-Wave RF Delivery: Your doctor applies the Sylfirm X handpiece across the treatment zones. The device uses 25 gold-plated, non-insulated surgical needles delivering 2 MHz RF energy at depths from 0.3mm to 3.5mm. Settings are adjusted zone-by-zone based on your treatment map — shallower PW for pigmentation, deeper CW for tightening.
  4. Post-Treatment Protocol: A calming, hydrating serum is applied immediately. Your skin will be red and feel warm, similar to a mild sunburn. We provide detailed Sylfirm X after care instructions before you leave.

The procedure itself takes 20-30 minutes for a full face. Including preparation and numbing, allow approximately 45-60 minutes for your appointment.

Step-by-Step: The Sylfirm X Clinical Protocol

Our medical team follows a precise 6-stage protocol to ensure optimal results from every Sylfirm X RF microneedling treatment.

1

Skin Analysis & Treatment Mapping

Your doctor analyses your skin type, pigmentation depth, vascular patterns, and primary concerns. Treatment zones are mapped and the appropriate RF wave mode is selected — Pulsed Wave for pigmentation and rosacea, Continuous Wave for tightening, or a combination approach.

2

Deep Cleanse & Anaesthesia

The treatment area is thoroughly cleansed to remove all oils and impurities. A topical anaesthetic cream is applied for 45-60 minutes to ensure a comfortable procedure.

3

Dual-Wave RF Calibration

The Sylfirm X device is calibrated with precise settings: needle depth (0.3mm-3.5mm), RF energy intensity, and wave mode selection based on your treatment map. Deeper settings for collagen remodelling, shallower for surface pigmentation and vascular targets.

4

Precision RF Microneedling Delivery

Your GMC-registered doctor systematically treats each mapped zone with the Sylfirm X handpiece. The 25 sterile gold-plated microneedles create controlled micro-channels while simultaneously delivering targeted 2 MHz radiofrequency energy to the dermis.

5

Post-Treatment Recovery & Serum Application

A calming, hydrating serum is applied immediately after treatment to support barrier recovery. Skin will be red and warm — this is the expected healing response.

6

Aftercare Briefing & Follow-Up

You receive detailed aftercare instructions covering sun protection, skincare product guidance, and expected recovery timeline. A follow-up review is scheduled to assess progress and plan subsequent sessions.

Sylfirm X vs Morpheus8: Which is Right for You?

Patients frequently ask is Sylfirm X better than Morpheus8 or search for Sylfirm X vs Morpheus8 comparisons. The answer depends entirely on your primary concern. Both are premium RF microneedling devices, but they are engineered for fundamentally different goals. Our clinic offers both, and our doctors will recommend the right device based on clinical assessment — not commercial preference.

FactorSylfirm XMorpheus8
RF TechnologyDual Wave (Pulsed + Continuous)Single Wave (Continuous only)
Treats Melasma/PigmentationYes — Pulsed Wave selectively targets melanocytesNot indicated — not designed for pigmentation concerns
Treats Rosacea/RednessYes — coagulates abnormal vesselsLimited/Not indicated
Safe for Darker Skin (Fitzpatrick IV-VI)Yes — validated across all skin typesYes — insulated needles protect epidermis
Deep Fat RemodellingNo — energy confined to dermisYes — penetrates subdermal fat
Skin TighteningYes — Continuous Wave collagen stimulationYes — deep thermal contraction
Acne Scar RemodellingYesYes
Pain LevelLow (with topical anaesthetic)Medium-High
Typical Downtime1-3 days redness3-7 days redness/swelling
Best ForPigmentation, rosacea, skin quality, all skin typesDeep tightening, jawline contouring, fat reduction

Our clinical verdict: For patients whose primary concerns include melasma, rosacea, overall skin quality, or who have darker skin tones, Sylfirm X is the superior and safer choice. For patients primarily seeking deep tissue tightening or submental fat reduction, Morpheus8 may be more appropriate.

Sylfirm X Cost in London

Patients searching for Sylfirm X cost or Sylfirm X treatment price should understand that pricing reflects three factors: the advanced dual-wave technology, the clinical expertise of GMC-registered doctors, and the quality of our dedicated medical aesthetic clinic at 33 Cavendish Square.

Our Sylfirm X price starts from £650 for eye area treatments. Full face, neck, and combination treatments are priced according to the areas treated. We offer package discounts for treatment courses of 3-5 sessions, which deliver the best clinical results and represent the best value.

For patients asking how much does Sylfirm X cost for their specific concerns, we provide a detailed quotation following your clinical assessment, as the treatment plan — including wave mode, number of sessions, and areas covered — is tailored to your individual needs.

Sylfirm X Side Effects & Safety Profile

Understanding Sylfirm X side effects is important for setting realistic expectations. The device has an excellent safety profile, underpinned by its FDA 510(k) clearance (K200185) and clinical validation across all Fitzpatrick skin types.

Expected Side Effects (Normal Recovery)

  • Redness (erythema): Universal and expected. Typically resolves within 1-3 days. This is the most common response patients describe in Sylfirm X reviews.
  • Mild swelling: May occur for 24-48 hours, particularly around the eyes.
  • Warmth and sensitivity: Skin will feel like a mild sunburn for 1-2 days.
  • Pinpoint bleeding or light crusting: Resolves within 48-72 hours. Part of the normal micro-channel healing process.
  • Temporary dryness: As the skin renews over the first week.

Rare or Unlikely Side Effects

  • Post-inflammatory hyperpigmentation: Extremely rare with Sylfirm X due to its precise energy delivery — significantly lower risk than other RF devices, even on darker skin tones.
  • Prolonged redness: Uncommon, typically resolves within 5-7 days if it occurs.

Does Sylfirm X Melt Fat?

A common concern — does Sylfirm X melt fat? No. Sylfirm X is engineered to deliver its energy precisely within the dermis. It does not penetrate the subcutaneous fat layer, so there is no risk of unwanted Sylfirm X fat loss. This is a key differentiator from devices like Morpheus8 that intentionally target deeper fat tissue.

For detailed information about potential risks, our medical team performs a thorough skin assessment and reviews your medical history before every treatment.

Sylfirm X Aftercare & Recovery

Proper Sylfirm X after care is essential to maximise your results and support healthy skin recovery. Sylfirm X downtime is minimal — most patients return to social activities within 1-2 days.

First 24-48 Hours

  • Keep the treated area clean. Use only the recommended gentle cleanser and moisturiser.
  • Avoid makeup, active skincare (retinoids, AHAs, vitamin C), and fragranced products.
  • Do not touch, pick, or scratch the treated area.
  • Apply prescribed post-treatment serum or barrier cream as directed.
  • Avoid direct sun exposure and apply SPF 50+ if going outdoors.

First 2 Weeks

  • Continue strict sun protection (SPF 50+ daily, reapply every 2 hours outdoors).
  • Avoid saunas, steam rooms, hot yoga, and intense exercise for 48-72 hours.
  • Gradually reintroduce your normal skincare routine after 5-7 days, as directed by your doctor.
  • Mild dryness and flaking is normal — do not exfoliate manually.

Follow-Up Review

A follow-up review is scheduled to assess your Sylfirm X recovery, document progress, and plan subsequent sessions in your treatment course.

Am I a Candidate for Sylfirm X?

Ideal CandidateMay Need an Alternative Approach
Melasma or stubborn pigmentation unresponsive to topicalsActive skin infection or open wounds in the treatment area
Rosacea, persistent redness, or broken capillariesCurrently taking Accutane/Isotretinoin (must wait 6 months)
Early signs of ageing: fine lines, mild laxity, dull skinUnrealistic expectations (e.g., expecting surgical-level lifting)
Acne scarring or uneven skin textureActive cystic acne in the treatment zone
All skin types including Fitzpatrick IV-VI (darker tones)Pregnancy or breastfeeding
Patients wanting minimal downtime vs. ablative lasersHistory of keloid scarring (requires individual assessment)
Periorbital concerns (hooded lids, crow's feet, dark circles)Implanted electronic devices near treatment area

Contraindications & Medical Considerations

While Sylfirm X is safe for all skin types, certain medical conditions require careful assessment or may preclude treatment:

  • Absolute contraindications: Active infection in the treatment area, pregnancy, breastfeeding, implanted electronic devices (pacemakers), current Isotretinoin use (within 6 months).
  • Relative contraindications (require assessment): History of keloid or hypertrophic scarring, uncontrolled diabetes, bleeding disorders, active autoimmune conditions affecting the skin, recent chemical peel or ablative laser within 4 weeks.
  • Not a contraindication (commonly misunderstood): Darker skin tones (Fitzpatrick IV-VI) are safe for Sylfirm X. Tanned skin is generally safe but should be assessed — we may recommend waiting for a tan to fade for optimal results.

All patients undergo a detailed medical history review and skin assessment during their consultation to confirm suitability.

Clinical Disclaimer

Sylfirm X RF Microneedling is a medical aesthetic procedure. Individual Sylfirm X results vary based on skin type, condition severity, age, and lifestyle factors. While the device is clinically validated for pigmentation, rosacea, skin rejuvenation, and scar remodelling, it is a treatment to manage and improve these conditions — not a permanent cure. Maintenance sessions are typically recommended every 12-18 months to sustain optimal results. A professional consultation with one of our GMC-registered doctors is essential to determine suitability and set realistic expectations. Content last medically reviewed: March 2026.

Sylfirm X Near Me: Expert Treatment at Cavendish Square

Searching for Sylfirm X near me or Sylfirm X treatment near me in London? PRP London Clinic is located at 33 Cavendish Square, London W1G 0PW — in the heart of the West End medical district, moments from Oxford Street.

We are a 4-minute walk from Oxford Circus station (Central, Bakerloo, Victoria lines) and a 5-minute walk from Bond Street station (Central, Jubilee, Elizabeth lines). Secure underground parking is available at Q-Park Oxford Street, located directly beneath Cavendish Square.

Every Sylfirm X London treatment is performed by a GMC-registered doctor using genuine, certified equipment and clinically backed protocols — offering Harley Street standards of care in the discreet comfort of Sylfirm X Cavendish Square.

Book Your Sylfirm X Consultation

Take the first step toward clearer, firmer, more radiant skin. Book a consultation with our medical team to discuss whether Sylfirm X treatment London is right for your skin concerns. Our GMC-registered doctors will assess your skin, recommend the optimal treatment plan, and answer any questions you have about the procedure, expected results, and costs.

Myths vs Facts

M

Sylfirm X is just like any other RF microneedling device.

F

Sylfirm X is the world's only dual-wave RF microneedling system. Its Pulsed Wave mode can selectively target abnormal blood vessels and melanocytes — something no other RF device can safely do.

M

RF microneedling is not safe for darker skin tones.

F

Sylfirm X's controlled energy delivery is clinically validated for all Fitzpatrick skin types (I-VI), including darker and tanned skin, with a significantly lower risk of post-inflammatory hyperpigmentation.

M

Sylfirm X causes facial fat loss like other RF devices.

F

Sylfirm X delivers energy precisely within the dermis. It does not penetrate the subcutaneous fat layer, eliminating the risk of unwanted facial volume loss.

M

You need weeks of downtime after Sylfirm X.

F

Downtime is typically 1-3 days of redness. Most patients return to social activities within 24-48 hours.

M

One session is enough for melasma.

F

While improvements are visible after a single session, a course of 3-5 sessions spaced 4-6 weeks apart is recommended for stubborn pigmentation conditions to achieve optimal, lasting results.

M

Sylfirm X results are temporary and fade quickly.

F

The collagen your body produces is permanent. With a completed course and proper skincare, results typically last 12-18 months. A single maintenance session annually sustains optimal skin quality.

Sylfirm X RF Microneedling Cost

TreatmentPrice
Sylfirm X for Eyes

Per session. Includes consultation and review. Specifically targets hooded eyelids, crow's feet, and periorbital laxity.

£350per treatment
Sylfirm X for Full Face

Per session. Includes consultation and review. Comprehensive treatment for texture, pores, pigment, melasma, and rejuvenation.

£495per treatment
Sylfirm X for Face & Neck

Per session. Includes consultation and review. Extends the full facial rejuvenation to the neck for harmonious results.

£645per treatment
Sylfirm X for Face, Neck & Décolletage

Per session. Includes consultation and review. Comprehensive rejuvenation for face, neck, and décolletage.

£795per treatment
Sylfirm X for Neck

Per session. Includes consultation and review. Targets neck laxity and texture.

£495per treatment
Sylfirm X for Décolletage

Per session. Includes consultation and review. Targets décolletage laxity and texture.

£495per treatment
Sylfirm X for Abdomen

Per session. Includes consultation and review. Body treatment for abdominal skin tightening.

£495per treatment
Sylfirm X for Inner Thigh

Per session. Includes consultation and review. Body treatment for inner thigh skin tightening.

£495per treatment
Sylfirm X for Full Thigh

Per session. Includes consultation and review. Body treatment for comprehensive thigh skin tightening.

£795per treatment

Prices are indicative. Please book a consultation for a personalised quote.

Frequently Asked Questions

At PRP London Clinic, Sylfirm X cost starts from £650 for eye area treatments. Full face, neck, and combination treatments are priced according to the areas treated. We offer package discounts for courses of 3-5 sessions, which deliver the best results and value. For a personalised Sylfirm X treatment price based on your specific concerns, book a consultation with our medical team.
Most patients benefit from a course of 3-5 Sylfirm X treatments spaced 4-6 weeks apart. You will see improvements after one session, but cumulative treatments deliver the most significant results — particularly for conditions like melasma and acne scarring. Our doctors will recommend the optimal number during your consultation based on how many treatments your specific condition requires.
Sylfirm X downtime is minimal compared to other RF microneedling devices. Expect redness and mild warmth (like a sunburn) for 1-3 days. Pinpoint bleeding or light crusting may occur but resolves within 48-72 hours. Most patients comfortably return to social activities within 24-48 hours.
No. We apply a strong topical anaesthetic cream for 45-60 minutes before your Sylfirm X treatment. Most patients report only a light pressure and mild warming sensation during the procedure. Pain is consistently rated as low in patient feedback.
Patients often ask how long does Sylfirm X last — the collagen produced by your body is permanent, but the ageing process continues. With a completed treatment course and good skincare, Sylfirm X results typically last 12-18 months. We recommend a single maintenance session annually to sustain optimal outcomes.
Initial improvements in skin texture and clarity may appear within 1-2 weeks. For Sylfirm X how long to see results, the full benefits develop over 6-12 weeks as your body produces new collagen. Pigmentation fading is progressive — most patients notice significant improvement by their second or third session.
No. This is a common concern, but Sylfirm X fat loss is not a risk. The device delivers RF energy precisely within the dermis and does not penetrate the subcutaneous fat layer. Unlike Morpheus8 (which intentionally targets fat at deeper settings), Sylfirm X preserves facial volume while tightening and rejuvenating the skin.
It depends on your primary concern. Is Sylfirm X better than Morpheus8 for pigmentation and rosacea? Yes — Sylfirm X's Pulsed Wave mode treats these conditions safely, while Morpheus8 cannot. For deep tissue tightening and fat remodelling, Morpheus8 penetrates deeper. Our clinic offers both devices, and our doctors will recommend the right one based on clinical assessment.
Sylfirm X side effects are typically mild and temporary: redness (1-3 days), warmth, mild swelling, and occasional pinpoint bleeding or crusting. Serious risks like post-inflammatory hyperpigmentation are extremely rare due to the device's precise energy delivery. For Sylfirm X side effects long term, there are no known lasting adverse effects when performed by trained medical professionals.
Yes. Sylfirm X is one of the only RF microneedling devices clinically validated as safe for all Fitzpatrick skin types (I-VI), including darker and tanned skin tones. The Pulsed Wave technology selectively targets abnormal tissue while leaving surrounding skin unaffected, making it significantly safer than traditional lasers and RF devices for darker skin.
Sylfirm X under eye treatment is one of the device's unique capabilities. It safely addresses dark circles (vascular origin), under-eye crepiness, fine lines, and thinning skin in the delicate periorbital area. Sylfirm X eyelids treatment can also tighten loose upper eyelid skin for a more lifted, open appearance without surgery.
For patients with melasma, rosacea, pigmentation, or skin quality concerns, is Sylfirm X worth it? Clinical evidence and our patient outcomes suggest yes — particularly if you have a condition that other devices cannot safely treat. The dual-wave technology addresses concerns that previously had no effective non-surgical solution. Results are cumulative and long-lasting with proper maintenance.
PRP London Clinic offers expert Sylfirm X London treatments at 33 Cavendish Square, London W1G 0PW. We are a 4-minute walk from Oxford Circus station and offer Harley Street standards of medical care. Every treatment is performed by a GMC-registered doctor using genuine, certified Sylfirm X equipment.
Sylfirm X after care involves keeping the skin clean and hydrated for the first 48 hours, avoiding makeup and active skincare (retinoids, AHAs), strict sun protection with SPF 50+, and avoiding saunas or intense exercise for 48-72 hours. Our doctors provide detailed aftercare instructions tailored to your specific treatment.

Clinical Evidence & Scientific References

Gulfan & Wanitphakdeedecha (2022): Noninsulated Microneedle RF for Melasma

M.C.B. Gulfan, R. Wanitphakdeedecha, S. Wongdama, N. Jantanapornchai, C. Yan, S. Rakchart · Dermatology and Therapy, 2022PMID: 35538360

Supports: Split-face, double-blind RCT of 30 patients (Fitzpatrick III-V) with melasma receiving 3 treatments of pulsed-type noninsulated microneedle RF (Sylfirm) at 2-week intervals. Significant improvements in melanin index, skin roughness, and mMASI scores at 6 months. Confirms the Sylfirm device is safe and effective for melasma with only a 10% recurrence rate over 6 months.

Limitations: Small sample size (30 patients, 26 completed follow-up). Single-centre study. Mixed melasma predominated (61.5%). The combination with polynucleotides did not show superiority over RF alone, limiting conclusions about combination protocols.

View on PubMed

Jung et al. (2021): Pulsed Bipolar RF for Facial Erythema in Rosacea & Acne

Y.J. Jung, Y.S. Ro, H.J. Ryu, J.E. Kim · Journal of Cosmetic and Laser Therapy, 2021PMID: 33650938

Supports: Clinical study of 31 patients with rosacea or acne vulgaris-related erythema receiving 2-5 sessions of invasive pulsed-type bipolar RF at 2-week intervals. Significant improvement in erythema index after the second treatment, maintained throughout the study period. IGA scores for erythema, pores, and smoothness all improved. No serious adverse events reported.

Limitations: Non-randomised study design without a control group. Relatively small sample size (31 patients). Variable number of treatment sessions (2-5) across patients, making dose-response assessment difficult.

View on PubMed

Ma et al. (2023): Laser-Related Therapy for Melasma — Network Meta-Analysis

W. Ma, Q. Gao, J. Liu, X. Zhong, T. Xu, Q. Wu, Z. Cheng, N. Luo, P. Hao · Journal of Cosmetic Dermatology, 2023PMID: 37737021

Supports: Systematic review and network meta-analysis of 39 RCTs (1,394 participants) comparing laser-related therapies for melasma MASI score improvement. Microneedling + topical medications ranked 3rd by SUCRA value (79.7%) — confirming that microneedling-based approaches are among the most effective modalities for melasma treatment and superior to picosecond laser or topical medications alone.

Limitations: Network meta-analysis relies on indirect comparisons between treatments not studied head-to-head. Included studies had heterogeneous protocols, follow-up periods, and Fitzpatrick skin type distributions. Does not specifically isolate RF microneedling from standard microneedling in its analysis.

View on PubMed

Niaz et al. (2025): FRM as Monotherapy for Acne Scars — Systematic Review

G. Niaz, Y. Ajeebi, H.M. Alshamrani, M. Khalmurad, K. Lee · Clinical, Cosmetic and Investigational Dermatology, 2025PMID: 39781098

Supports: Systematic review of 16 studies (481 patients) confirming fractional radiofrequency microneedling is an effective monotherapy for atrophic acne scarring. Over 80% of patients achieved a two-grade scar improvement. FRM considered safer for darker skin tones with minimal adverse effects (transient erythema). Moderate-to-high patient satisfaction with improved quality of life.

Limitations: Heterogeneous study designs (6 prospective, 6 RCTs, 3 retrospective, 1 comparative). Variable FRM device types, settings, and treatment protocols across studies. Further RCTs needed to establish standardised treatment parameters. Does not specifically evaluate Sylfirm X — findings apply to FRM as a device class.

View on PubMed

*PRP London Clinic provides these references for educational purposes. Our Clinical Board regularly reviews emerging peer-reviewed literature to ensure our protocols align with the latest advancements in regenerative medicine.

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Medical Suitability Note

As a GMC-regulated practice, a mandatory consultation is required for all new patients to assess suitability and clinical need. This treatment may not be appropriate for everyone. All procedures are performed by GMC-registered doctors whose credentials can be verified on the official GMC register.

Clinical Technology & Equipment

Medical Device

SYLFIRM X™

by SYLFIRM X

Manufacturer Info →

Advanced bipolar, pulsed-type microneedling radiofrequency (RF) device. The only FDA-cleared Dual Wave system (CW + PW) for targeted electrocoagulation and vascular rejuvenation.

Certifications

FDA 510(k) K200185 Product Code: GEI Regulation: 21 CFR 878.4400

Technical Specifications

RF Frequency
2 MHz
Needle Type
25 Non-insulated gold-plated surgical needles
Penetration Depth
0.3 mm to 3.5 mm

Clinical Applications

Melasma and PIH Treatment Skin Laxity and Sagging Neovascularization (Rosacea)

This technical specification is provided for informational purposes only. All medical devices and substances are used exclusively by GMC-registered practitioners at PRP London Clinic. Individual results may vary.