Hendricks & Farhang (2022): Dermatologic facial applications of Morpheus8 fractional radiofrequency microneedling
Aleksi J. Hendricks, Sheila Z. Farhang · Journal of Cosmetic Dermatology, 2022PMID: 35916259
Supports: Describes Morpheus8 fractional RF microneedling as an effective method for addressing skin laxity, acne, scarring, and multiple dermatologic conditions with reduced downtime compared to more invasive procedural approaches.
Limitations: Narrative review rather than systematic review or meta-analysis; describes studied applications without pooling quantitative outcome data or conducting statistical comparison across studies.
View on PubMed →Suh et al. (2023): Clinical and histological evaluation of microneedle fractional radiofrequency treatment on facial fine lines and skin laxity in Koreans
Dong Hye Suh, Minah Cho, Hyeong Seob Kim, Sang Jun Lee, Kye Yong Song, Hei Sung Kim · Journal of Cosmetic Dermatology, 2023PMID: 36718800
Supports: Demonstrates that bipolar microneedle fractional RF achieves histologically confirmed neo-collagenesis and neo-elastogenesis, with 86.7% patient satisfaction and 100% of patients rated improved or better by independent dermatologists at 4-month follow-up after a single session.
Limitations: Small sample size (n=15), retrospective design, single treatment session, ethnically homogeneous cohort (Korean), and 4-month follow-up may not capture long-term durability of results.
View on PubMed →Niaz et al. (2025): Fractional Radiofrequency Microneedling as a Monotherapy in Acne Scar Management: A Systematic Review of Current Evidence
Ghassan Niaz, Yara Ajeebi, Hussein M. Alshamrani, Murad Khalmurad, Kachiu Lee · Clinical, Cosmetic and Investigational Dermatology, 2025PMID: 39781098
Supports: Systematic review of 16 studies (481 patients) confirms fractional radiofrequency microneedling is likely effective as a monotherapy for treating different types of facial acne scarring, supporting its use across prospective studies, RCTs, and retrospective analyses.
Limitations: Heterogeneity in treatment parameters across included studies; authors note further RCTs are needed to establish standardised protocols. No pooled meta-analytic effect size reported.
View on PubMed →Syder et al. (2023): Radiofrequency and Radiofrequency Microneedling in Skin of Color: A Review of Usage, Safety, and Efficacy
Nicole C. Syder, Alessandra Chen, Nada Elbuluk · Dermatologic Surgery, 2023PMID: 36826381
Supports: Systematic review of 35 articles confirms RF and RF microneedling have a low risk of scarring or hyperpigmentation in Fitzpatrick skin Types III–VI, with successful application for rhytides, acne scarring, and skin rejuvenation across darker skin tones.
Limitations: A large proportion of included studies lack strong quality evidence; review covers 2000–2021 literature so newer device iterations may not be represented; no meta-analytic pooling of outcomes.
View on PubMed →Alexiades & Munavalli (2021): Single Treatment Protocol With Microneedle Fractional Radiofrequency for Treatment of Body Skin Laxity and Fat Deposits
Macrene Alexiades, Gilly S. Munavalli · Lasers in Surgery and Medicine, 2021PMID: 33764552
Supports: Registered clinical trial (n=31, 62 treatment areas) demonstrates a single microneedle fractional RF session improves body skin laxity and localised fat deposits, with 100% of upper arm subjects showing improvement at all timepoints (1, 3, 6 months) and up to 92% for suprapatellar regions.
Limitations: Moderate sample size (31 subjects), all female, Fitzpatrick I–IV only (no darker skin types), 6-month follow-up may not capture long-term durability, no control/sham arm.
View on PubMed →*PRP London Clinic provides these references for educational purposes. Our Clinical Board regularly reviews emerging peer-reviewed literature to ensure our protocols align with the latest advancements in regenerative medicine.