PRF Facial London: Platelet-Rich Fibrin Skin Rejuvenation

A PRF facial london at PRP London Clinic combines medical-grade microneedling with injectable Platelet-Rich Fibrin (I-PRF) to deliver sustained growth factor stimulation to the skin. Unlike a standard PRP facial, PRF microneedling uses a fibrin matrix that continues releasing growth factors for 10 to 14 days after treatment — providing a prolonged regenerative stimulus for collagen synthesis, elastin production, and cellular renewal.

At 33 Cavendish Square, London W1G, our GMC-registered doctors use the T-Lab PRF System (CE Class IIB) for all PRF facial treatments. A 2025 systematic review of 20 studies (514 patients) found PRP/PRF treatment significantly improved skin thickness in 80% of studies and elasticity in 75% of studies, with all studies reporting positive patient satisfaction and no serious adverse events.

For patients seeking volumisation rather than surface skin improvement, see our PRF Biofiller / EZ Gel page. For the standard PRP approach, see PRP Facial.

Every PRF facial london session is performed by a GMC-registered doctor from our clinical team — Dr Bruno Amendola (GMC: 4346629), Dr Mohamed Nafei (GMC: 7520509), and Dr Reem Nouri (GMC: 6149512). Our doctors follow standardised PRF facial rejuvenation treatment protocols developed through shared clinical workflows, ensuring consistent outcomes regardless of which physician performs your procedure. Never a nurse, technician, or non-medical practitioner.

Sustained Growth Factor Delivery to Skin

When I-PRF is applied to the skin following microneedling, the fibrin matrix integrates with the microchannels created in the dermis. Growth factors including PDGF, TGF-β, VEGF, and EGF are released gradually over 10–14 days, stimulating fibroblast proliferation, new collagen formation, and improved skin vascularity from within.

Skin Texture and Elasticity

A 2025 systematic review of 20 studies confirmed that PRP/PRF treatment significantly improves skin thickness (80% of studies) and elasticity (75% of studies). The sustained release mechanism of PRF may provide a more prolonged regenerative stimulus compared to standard PRP application.

PRF for Lips

PRF lips treatment uses injectable PRF to improve lip texture, hydration, and fine perioral lines. The sustained growth factor delivery stimulates collagen renewal in the lip vermilion and surrounding skin — a natural approach to lip rejuvenation without synthetic fillers.

Neck and Décolletage

PRF microneedling can be extended to the neck and décolletage — areas commonly affected by sun damage, crepiness, and loss of elasticity. The same sustained growth factor delivery mechanism stimulates collagen renewal in these often-neglected treatment zones.

Under-Eye and Tear Trough

For periorbital concerns including dark circles, crepey skin, and tear trough hollowing, we offer PRF as a separate dedicated treatment. See our PRF/PRP Under Eyes page for details. For deeper volume restoration, our PRF Biofiller / EZ Gel may be more appropriate.

T-Lab PRF System for Facial Treatment

All PRF facial treatments are prepared using the T-Lab PRF System with the I-PRF protocol — 1500 RCF for 4 minutes. This produces a liquid fibrin concentrate optimised for topical application following microneedling, or for direct micro-injection into specific treatment zones.

Microneedling with PRF

Microneedling with PRF combines two complementary mechanisms: the microneedling device creates thousands of controlled microchannels in the dermis, stimulating a wound-healing response. The I-PRF is then applied topically, allowing the fibrin matrix and its growth factors to penetrate into the dermal layer through these channels. Needle depth is adjusted for each treatment zone — shallower for delicate periorbital skin, deeper for cheeks and jawline.

Treatment Zone Adaptations

• Full face — microneedling + topical PRF across forehead, cheeks, jawline, chin
• Lips — micro-injection of I-PRF into the lip vermilion and perioral lines
• Neck / décolletage — extended treatment area for sun-damaged or crepey skin

Under-eye treatments are offered as a separate dedicated session — see our PRF/PRP Under Eyes page.

Here is what to expect during your PRF facial london appointment:

PRF facial london at PRP London Clinic starts from £400 per session. A course of 3 sessions is recommended for optimal results.

Your consultation includes a full skin assessment, discussion of expected outcomes, and a clear treatment plan with itemised pricing. See the pricing table below for a full breakdown.

The PRF facial has an excellent safety profile. A 2025 systematic review of 20 studies (514 patients) reported no serious adverse events across any included study, with all studies reporting positive patient satisfaction.

Temporary side effects may include:

• Redness and mild swelling for 24–48 hours (expected following microneedling)
• Minor bruising at injection points
• Temporary skin sensitivity
• Occasional pinpoint bleeding at injection sites

All treatments are performed under sterile conditions by our GMC-registered doctors using single-use T-Lab PRF tubes and medical-grade microneedling devices.

First 24–48 Hours

• Do not apply makeup for at least 6–12 hours
• Avoid touching, rubbing, or applying pressure to the treated area
• Skip strenuous exercise, saunas, steam rooms, and swimming pools
• Avoid direct sun exposure
• Avoid anti-inflammatory medications (ibuprofen, aspirin)
• Use only gentle, fragrance-free cleanser and moisturiser

First 2 Weeks

• Apply SPF 50 daily — the skin is more sensitive to UV following microneedling
• Avoid active skincare ingredients (retinoids, AHAs, BHAs, vitamin C serums) for 5–7 days
• Maintain good hydration

Follow-Up

Your doctor will schedule a follow-up to assess your skin's response and discuss timing for your next session. Most PRF facial protocols recommend 3 sessions spaced 4–6 weeks apart, followed by maintenance every 3–6 months.

A PRF facial is not suitable for everyone. The following conditions are screened during your consultation:

• Platelet dysfunction syndrome or critical thrombocytopenia
• Active malignancy (cancer)
• Active facial skin infection — herpes simplex, impetigo, or bacterial infection
• Active acne or rosacea flare — treatment deferred until controlled
• Recent isotretinoin use — within 6 months
• Blood-thinning medication — requires medical review
• Pregnancy or breastfeeding
• Chronic liver disease

A PRF facial is a biological medical procedure combined with microneedling. Individual results vary based on age, skin type, baseline skin condition, and lifestyle factors. While clinical evidence supports PRF/PRP improvements in skin thickness and elasticity, PRF is a treatment to support natural skin regeneration — it is not a guaranteed solution for all skin concerns. A professional consultation is required to determine suitability.

Last medical review: March 2026.

PRP London Clinic is located at 33 Cavendish Square, London W1G 0PW — in the heart of London's medical district. Our dedicated clinical premises provide a private, professional environment for all PRF facial london treatments.

Ready to explore how a PRF facial can improve your skin texture, elasticity, and fine lines? Book a consultation with one of our GMC-registered doctors. We'll assess your skin, discuss whether PRF, PRP, or a combination approach is best, and create a personalised treatment plan.