Sunekos® London

Sunekos London at PRP London Clinic is a doctor-administered injectable protocol that combines non-crosslinked hyaluronic acid (HA) with the patented HY6AA cluster of six amino acids — glycine, proline, lysine, leucine, valine and alanine — to stimulate fibroblasts and rebuild the skin's extracellular matrix (ECM) by triggering new endogenous collagen, elastin and hyaluronic acid synthesis. Unlike traditional dermal fillers which add volume, Sunekos® works biologically to improve skin quality, hydration, elasticity and fine line appearance from the inside out.

At 33 Cavendish Square, London W1G, our GMC-registered doctors use two formulations: Sunekos® 1200 for deeper biostimulation of the face on the first session, and Sunekos® Performa — the next-generation pre-mixed formula that has replaced the older Sunekos 200 — for under-eye treatment and for second and third facial top-up sessions. The full Sunekos treatment course is three sessions, 4–6 weeks apart, allowing the skin time to remodel between visits.

Patients in London search for Sunekos when they want measurable skin quality improvement without the volumising effect of HA fillers, or when they have periorbital concerns (under-eye fine lines, crepey skin, mild dark circles) that are unsuitable for thicker bioremodelling products like Profhilo. Sunekos treatment in London is suitable for the face, neck, décolletage and — critically — the delicate under-eye area where many other skin boosters cannot safely be used.

All Sunekos® injections at PRP London Clinic are performed by GMC-registered doctors — never by nurses, technicians or non-medical practitioners. Dr Mohamed Nafei (GMC: 7520509), Dr Reem Nouri (GMC: 6149512) and Dr Bruno Amendola (GMC: 4346629) each deliver Sunekos® London using shared clinical workflows and standardised injection protocols — so whichever clinician treats you, the technique, dose-mapping for face versus under-eye, and aftercare guidance are clinically aligned. Combined experience across more than three decades of medical and aesthetic practice underpins every Sunekos treatment, with each doctor independently trained in advanced skin booster, polynucleotide and HA injectable techniques.

This patient came to our London clinic to improve overall skin quality. Her skin looked shiny and uneven, with visible vascular shadowing, the faint purple tone under the eyes, where the skin is thinnest.

She had a doctor-led course of Sunekos® with Dr Mohamed Nafei. The first session combined Sunekos® 1200 and Sunekos® Performa injected across the face; the following sessions used Sunekos® Performa. Sunekos is injected rather than microneedled, and works by deeply hydrating the skin, which improves texture and can make fine lines look softer as the skin appears plumper and healthier.

In the before and after photos below you can see more hydrated, more even skin and reduced vascular shadowing under the eyes. Many patients also find their skincare absorbs better afterwards, as more hydrated skin takes up moisturiser and serums more effectively. Sunekos also pairs well with polynucleotides, the added hydration helps create a better environment for the polynucleotides to work.

Skin Quality & Bioremodelling for the Face

Sunekos® face treatment in London is designed for patients whose skin is showing early laxity, dehydration, dullness or fine wrinkling but who do not need or want added volume. The HY6AA amino acid cluster activates fibroblasts to upregulate type-I and type-III collagen and elastin, while the non-crosslinked HA provides immediate dermal hydration and a substrate for ECM remodelling. The result is improved skin elasticity, smoother texture and a healthier appearance — without the volumising or facial-shape-changing effect of dermal fillers.

Under-Eye Fine Lines, Crepey Skin & Mild Dark Circles

Sunekos under eye London is one of the most popular applications of the product. Sunekos® Performa is specifically suitable for the delicate periorbital area because its hyaluronic acid is non-crosslinked and low molecular weight, meaning it does not retain the kind of water mass that causes puffiness — a known issue with thicker, crosslinked HA boosters and bioremodelling products such as Profhilo in this area. Sunekos for dark circles London is most effective where the discolouration is partly driven by thin, crepey skin and lost ECM rather than purely vascular shadowing or true hollowing (which may need polynucleotides or tear-trough filler instead).

Neck & Décolletage Skin Quality

Sunekos® can be used off the face on the neck and décolletage to address crepey skin texture, fine lines and loss of elasticity in areas frequently affected by photo-ageing.

Adjunctive Regenerative Protocols

Sunekos® is frequently combined with polynucleotide injections, PRP or exosome treatments to layer different regenerative mechanisms — Sunekos addressing ECM regeneration via HA and amino acids, polynucleotides delivering DNA-fragment bio-stimulation, and PRP/exosomes contributing autologous growth factors and signalling molecules. Combination protocols are recommended only where the clinical picture supports it, not as a default upsell.

Peri-Menopausal & Post-Menopausal Skin Quality Decline

Falling oestrogen accelerates collagen and HA loss, often producing a noticeable change in skin quality, hydration and elasticity over 12–24 months. Sunekos® biostimulation is a well-tolerated option for patients in this group who want regenerative skin quality improvement without volumising procedures.

We stock two Sunekos® formulations at our London clinic: Sunekos® 1200 and Sunekos® Performa. We do not stock Sunekos® 200 because Performa is the next-generation pre-mixed replacement for the older Sunekos 200 formulation.

Both products are CE-marked Class III medical devices manufactured by Professional Dietetics S.p.A. — the inventors of the HY6AA formula.

Injection Technique

All Sunekos® injections at PRP London Clinic are performed using a fine-gauge needle. We do not use cannulas for Sunekos — the protocol is needle-only, with the product delivered as a series of micro-deposits across the treatment area following standardised injection mapping. Needle technique allows precise intradermal placement at the depth where fibroblast biostimulation is most effective.

Anaesthesia & Comfort

Topical anaesthetic cream is applied as standard for under-eye Sunekos® Performa treatment, given the sensitivity of the periorbital area. Topical numbing is offered for facial Sunekos sessions as required. Most patients describe the treatment as well tolerated.

Facial Protocol — Session 1 vs Sessions 2 & 3

The first facial Sunekos session combines Sunekos® 1200 with Sunekos® Performa to deliver deeper structural biostimulation alongside the lower molecular weight ECM-regeneration formula. Sessions two and three of the facial course use Sunekos® Performa only — this is why the first appointment is priced higher than subsequent top-ups in our pricing schedule.

Under-Eye Protocol

The under-eye protocol uses Sunekos® Performa only. Three sessions, 4–6 weeks apart, are recommended for optimal ECM regeneration in the periorbital region. Placement is conservative, with micro-deposits avoiding the vascular structures of the orbital rim and tear trough.

Why a 4–6 Week Interval Matters

The fibroblast response to HA + amino acid biostimulation peaks over several weeks. Treating again too soon does not give the dermis time to remodel and lay down new collagen and elastin. 4–6 weeks between sessions is the protocol that consistently delivers measurable skin quality improvement.

Every Sunekos® patient at PRP London Clinic follows the same clinical protocol, regardless of which doctor treats them.

Sunekos vs Profhilo London is one of the most common questions our skin booster patients ask. Both are CE-marked injectables in the skin booster category, but they work differently and are suitable for different anatomical areas.

Many of our patients have both — Profhilo for face and neck hydration plus Sunekos® Performa for the under-eye area where Profhilo cannot safely be used.

Sunekos® treatment at PRP London Clinic starts from £250 per session. Sunekos cost London varies depending on whether you are treating the under-eye area only, the full face, or combining Sunekos with another regenerative product. The first facial session is priced higher than top-ups because it uses Sunekos® 1200 in combination with Sunekos® Performa, whereas sessions two and three use Performa only.

See the pricing table below for full per-session and full-course pricing including under-eye, face, face package of three, and the recommended combination protocols with polynucleotides. Combination protocols may be appropriate where you have mixed concerns — for example crepey under-eye skin plus visible tear-trough hollowing or dark circles — and are discussed during your consultation.

As a dedicated medical aesthetic clinic operating from a single doctor-led site at 33 Cavendish Square, our pricing reflects GMC-registered physician administration, CE-marked product sourcing and standardised clinical protocols — not nurse or technician delivery.

Published systematic reviews of hyaluronic acid injectables consistently report a favourable safety profile with predominantly mild, transient adverse events, although risk cannot be eliminated entirely from any injectable medical procedure. Sunekos® uses non-crosslinked HA, which has a different and typically gentler adverse event profile than crosslinked HA fillers.

Common side effects (temporary): Mild injection-site swelling, bruising, redness, tenderness or small palpable bumps that resolve within hours to days. Bruising typically resolves within 7–10 days. Topical anaesthetic minimises discomfort, particularly for under-eye treatment.

Less common: Pinpoint bleeding, transient itching, prolonged swelling beyond 72 hours, or a localised hypersensitivity-type reaction. These are uncommon and self-limiting when standard injection technique is followed.

Rare: True allergic reaction to hyaluronic acid or to any of the six amino acids in the HY6AA cluster, vascular events (theoretically possible with any facial injectable, mitigated by needle technique, anatomical knowledge and conservative depth), and infection (mitigated by sterile single-use product and clinic-grade aseptic technique).

Our safety protocols: Every Sunekos session is performed by a GMC-registered doctor in a dedicated medical aesthetic clinic with emergency-response equipment and protocols on site. We follow a strict no-treatment policy where Sunekos is not the right clinical choice, and we maintain detailed clinical records, photographic documentation and structured follow-up review at 4 weeks after each session.

First 24–48 Hours

• Avoid touching, rubbing or applying make-up to injection sites for at least 12 hours
• Avoid strenuous exercise, heat (saunas, hot showers, hot yoga) and alcohol
• Sleep face-up where possible on the first night
• Use cool compresses if you notice swelling or bruising

First Two Weeks

• Avoid facial treatments such as deep facials, peels, microneedling or laser in the treatment area
• Avoid prolonged direct sun exposure and use SPF 30+ daily
• Mild bruising and small bumps may persist for several days — these are normal and resolve on their own

Follow-Up Review

We invite all patients back at 4 weeks for review and to confirm the timing of the next session in the course. Your doctor will photograph progress under standardised lighting and discuss any adjustments to the protocol for sessions two and three.

Sunekos® is well tolerated by most adults, but the following are absolute or relative contraindications and will be assessed at consultation:

• Pregnancy or breastfeeding — no safety data supports use during these periods
• Active skin infection, inflammation or open wounds in the treatment area — postpone until fully resolved
• Known hypersensitivity to hyaluronic acid or to any of the six amino acids in the HY6AA cluster (glycine, proline, lysine, leucine, valine, alanine)
• Active autoimmune or inflammatory skin disease in the treatment zone, including active eczema, psoriasis flare or rosacea flare
• Bleeding disorders or concurrent therapeutic anticoagulation that materially increases bruising risk — assessed individually
• Recent semi-permanent fillers or biostimulators in the same treatment plane — timing assessed during consultation
• Unrealistic expectations of volumising or dramatic instant change — Sunekos is regenerative and gradual; we will redirect you toward the appropriate treatment if needed

This page is for information only and does not constitute medical advice. Sunekos® (1200 and Performa) is a CE-marked Class III medical device. Suitability, expected results and risks vary between patients and require a face-to-face clinical assessment by a GMC-registered doctor at our London clinic. Individual results from skin booster injectables vary based on age, baseline skin quality, lifestyle and adherence to the recommended 3-session course. Last medical review: May 2026, by Dr Bruno Amendola (GMC: 4346629).

PRP London Clinic is located at 33 Cavendish Square, London W1G 0PW — a short walk from Bond Street and Oxford Circus tube stations, in the heart of the Harley Street medical district. We offer Sunekos London appointments Monday to Saturday with same-week availability for new and existing patients searching for Sunekos near me, Sunekos Harley Street or skin-booster clinics in central London.

Ready to discuss whether Sunekos® is the right regenerative option for your skin? Book a consultation with one of our GMC-registered doctors at 33 Cavendish Square. We will assess your skin, explain the 3-session protocol, and confirm whether Sunekos® 1200 + Performa is the most appropriate plan — or whether a different or combination approach better suits your concerns. Read more about our medical team on Dr Bruno Amendola's profile or contact us via WhatsApp for a free consultation.