Juläine of Sweden PLLA collagen-stimulating treatment at PRP London Clinic, London W1G 0PW, for firmer, naturally radiant skin
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Juläine® (PLLA Collagen Biostimulator)

Juläine Treatment in London

GMC-registered doctors administer Juläine® of Sweden, a PLLA collagen-stimulating injectable that rebuilds your own collagen, at 33 Cavendish Square, London W1G 0PW

Duration

30 to 45m

Sessions

3

Price From

£895

Downtime

Minimal

Key Benefits

  • Collagen biostimulator, rebuilds your own collagen rather than adding instant filler volume
  • Newer-generation PLLA bio-activator, developed and made in Sweden by Nordberg Medical (CE-marked)
  • Natural, gradual result that develops over about 2 to 3 months
  • Long-lasting results, typically 12 to 24 months
  • PLLA has been used in medicine for over 40 years and in aesthetics for over 25 years
  • Doctor-only injection by GMC-registered physicians, never nurse or technician delivery
  • Combinable with skin boosters, polynucleotides and other treatments
  • Long-lasting collagen support, popular for 'collagen banking'

Common Target Areas

Face (cheeks, temples, lower face skin quality and firmness) Under-eye / periorbital support Neck and Décolletage

What is Juläine?

Juläine treatment (often written Julaine) at PRP London Clinic is a doctor-administered collagen-stimulating injectable that works with your body to rebuild its own collagen. Juläine® of Sweden is a PLLA (poly-L-lactic acid) collagen bio-activator, developed and manufactured in Sweden by Nordberg Medical and CE-marked: rather than adding instant volume like a dermal filler, it is injected into the skin where it gradually stimulates the production of new Type I collagen over the weeks and months that follow. The result is a natural, progressive improvement in firmness, skin quality and youthful support.

Juläine is a newer generation of PLLA biostimulator, made from poly-L-lactic acid microspheres. It is given as a course of treatments and produces a gradual, natural improvement in skin firmness and quality.

Doctor-Led Juläine Treatment in London

Every Juläine treatment at PRP London Clinic is performed by a GMC-registered doctor, never by a nurse, technician or non-medical practitioner. Dr Mohamed Nafei (GMC: 7520509), Dr Reem Nouri (GMC: 6149512) and Dr Bruno Amendola (GMC: 4346629) each deliver Juläine using shared clinical workflows and standardised injection protocols, so whichever clinician treats you the technique and aftercare guidance are clinically aligned.

How Juläine Injections Work

Juläine injections work by prompting your skin to make its own collagen. Once the PLLA is placed in the deeper layers of the skin, it acts as a collagen biostimulator. Over the following weeks, your body gradually lays down new collagen, improving firmness, support and skin quality. Because the improvement comes from your own collagen, it builds slowly and looks natural.

  • Collagen stimulation: encourages new Type I collagen production for firmer, better-supported skin.
  • Gradual, natural result: changes develop over about two to three months rather than appearing instantly.
  • Newer-generation PLLA: a Swedish-made, CE-marked PLLA bio-activator given as a course for a gradual, natural result.
  • Doctor-only delivery: administered by a GMC-registered doctor for correct depth and placement.

Unlike a hyaluronic acid skin booster such as Profhilo, which mainly hydrates and bio-remodels, Juläine is a biostimulator focused on longer-term collagen production. Often searched for as a 'Juläine skin booster', it is technically a collagen biostimulator, which works by a different mechanism. Your doctor will advise whether Juläine, a skin booster, or a combination best suits your skin.

Juläine Before and After

Juläine before and after results appear gradually. Because Juläine stimulates your own collagen, the improvement builds over about two to three months and continues across the recommended course. Each case below notes its source and the practitioner who performed it. Individual results vary.

For more Juläine before and after results, reviews, and how it compares with Sculptra and Profhilo, see our Juläine before and after guide.

Nasolabial Folds

Nasolabial Fold Improvement at 2 Months: Softening of the nasolabial fold and improved skin quality two months after the first Juläine session, as the treatment stimulates new collagen. Result from the official Juläine clinical portal.

Image courtesy of the official Juläine clinical portal. Clinic: The Faculty; injecting practitioner: Therese Von Post. Individual results vary. A consultation with a GMC-registered doctor is required before treatment.

Nasolabial Folds

Lower-Face and Nasolabial Fold Result at 2 Months: Softer nasolabial folds and improved skin quality around the mouth and lower face, two months after the first Juläine session. Result from the official Juläine clinical portal.

Image courtesy of the official Juläine clinical portal. Clinic: Entouch; injecting practitioner: Annika Harlén. Individual results vary. A consultation with a GMC-registered doctor is required before treatment.

Nasolabial Folds

Nasolabial Fold and Lower-Face Result After the Second Session: Continued softening of the nasolabial folds and smoother, better-quality skin around the mouth and lower face, two months after the second Juläine session. Result from the official Juläine clinical portal.

Image courtesy of the official Juläine clinical portal. Clinic: Entouch; injecting practitioner: Annika Harlén. Individual results vary. A consultation with a GMC-registered doctor is required before treatment.

Juläine Treatment Price

Juläine treatment price at PRP London Clinic is charged per vial, from £895 for the first vial. Additional vials on the same day are charged at a reduced rate (for example, two vials from £1,590). The standard Juläine course is three sessions, two to four weeks apart, for the best collagen-building result; your doctor may advise a different interval, and your exact plan and number of vials are confirmed at consultation. For the full breakdown see the price table, or book a consultation with one of our GMC-registered doctors.

Juläine for Under Eyes

Juläine under eyes: as a collagen biostimulator, Juläine can help improve skin quality and firmness in the delicate periorbital and cheek area as part of a wider collagen-building plan. For under-eye hollowing and dark shadowing specifically, it is often compared with or combined with targeted under-eye options, see our tear trough filler treatment and polynucleotide under-eye treatment. Your doctor will assess the under-eye area carefully and recommend the safest, most effective approach for you.

Juläine vs Sculptra and Profhilo

Juläine vs Sculptra: both are PLLA (poly-L-lactic acid) collagen biostimulators that work by stimulating your own collagen gradually over the weeks and months after treatment. Juläine is a newer PLLA bio-activator, developed and manufactured in Sweden by Nordberg Medical and CE-marked. Both are given as a course of sessions and produce a natural, progressive result. Sculptra is a well-established biostimulator; your doctor will advise which suits your skin.

Compared with Profhilo, a hyaluronic acid bio-remodeller that mainly hydrates and remodels the skin, Juläine focuses on longer-term collagen stimulation. These treatments can be complementary, and your doctor will advise which suits your goals.

What to Expect During a Juläine Session

A Juläine session is straightforward. After a clinical assessment and skin prep, Juläine is reconstituted and injected into the planned areas of the face using a needle or blunt cannula at the correct depth. A topical anaesthetic can be applied for comfort. A treatment usually takes around 30 to 45 minutes. Your doctor will give you personalised aftercare advice. This usually includes gently massaging the treated area with a moisturiser in the days after treatment, and avoiding strong sun or UV exposure and very hot or cold temperatures until any swelling and redness settle.

Step-by-Step: Your Juläine Treatment Journey

Your Juläine treatment at PRP London Clinic follows a structured, doctor-led pathway.

1

Clinical Assessment & Consultation

Your GMC-registered doctor reviews your medical history, examines your skin and facial structure, and confirms whether Juläine is the right collagen-building option, or whether a skin booster, filler or combination would suit your concern better.

2

Treatment Planning

The doctor plans the treatment areas and the number of Juläine vials and sessions needed for a natural, gradual result.

3

Treatment

Juläine is injected at the correct depth using a needle or cannula. A topical anaesthetic can be applied first for comfort. A session usually takes 30 to 45 minutes.

4

Collagen Builds & Review

Your own collagen builds gradually over the following weeks. Further sessions are typically scheduled around 2 to 4 weeks apart to complete the standard course of three sessions (your doctor may advise a different interval), with results developing over about two to three months.

Juläine Side Effects, Safety & Aftercare

Juläine is CE-marked for safety and quality and is generally well tolerated when administered by an experienced GMC-registered doctor. As the manufacturer notes, it is common to have some swelling, bruising and short-term discomfort around the injection sites immediately after treatment, along with redness or tenderness, which usually settle within a few days. Less commonly, small bumps or firmness can occur at injection points. Your doctor will explain the risks, confirm your suitability at consultation, and review your progress across the course.

Is Juläine Right for You?

Juläine suits people who want a gradual, natural improvement in skin firmness and quality rather than instant volume, for example, those noticing early skin laxity, loss of collagen with age, volume or quality loss following weight loss, or generally dull, crepey skin. It is also popular for 'collagen banking' as part of a longer-term skin plan. Juläine is not suitable during pregnancy or breastfeeding, where there is active skin infection, or with a known hypersensitivity to PLLA, your doctor will confirm suitability at consultation.

Clinical Disclaimer

This page is for information only and does not constitute medical advice. Juläine® is a collagen-stimulating injectable administered by prescription following clinical assessment. Suitability, expected results and risks vary between patients and require a face-to-face consultation with a GMC-registered doctor at our London clinic. Individual results from collagen biostimulators vary based on age, skin condition, lifestyle and adherence to the recommended course.

Juläine Treatment in London, Cavendish Square, W1G

PRP London Clinic is located at 33 Cavendish Square, London W1G 0PW, a short walk from Bond Street and Oxford Circus tube stations, in the heart of the Harley Street medical district. We offer Juläine appointments Monday to Saturday with same-week availability, and we see patients from across central London looking for Juläine on Harley Street and doctor-led collagen-biostimulator care.

Book Your Juläine Consultation in London

Ready to find out whether Juläine is right for your skin? Book a consultation with one of our GMC-registered doctors at 33 Cavendish Square. We will assess your skin, explain the collagen-building timeline, and confirm the right Juläine plan, or a different or combination approach, for your goals. Read more about our medical team on Dr Mohamed Nafei's profile or contact us via WhatsApp for a consultation.

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Myths vs Facts

M

Juläine is a dermal filler.

F

No. Juläine is a PLLA collagen biostimulator. It does not add instant volume like a filler, it stimulates your own collagen to build gradually for a natural improvement in firmness and skin quality.

M

You see the result straight away.

F

No. Because Juläine works by stimulating your own collagen, results build over about two to three months and continue to develop across the recommended course.

M

Juläine is exactly the same as Sculptra.

F

Both are PLLA biostimulators. Juläine is a newer PLLA bio-activator made in Sweden by Nordberg Medical. Both are given as a course and build collagen gradually; your doctor will advise which suits you.

M

One session is enough.

F

The standard Juläine course is three sessions, spaced around 2 to 4 weeks apart, for the best collagen-building result. Your doctor may advise a different interval and will confirm your plan at consultation.

Juläine® (PLLA Collagen Biostimulator) Cost

TreatmentPrice
Juläine® (First Vial)

PLLA collagen biostimulator. Price for the first vial.

£895per treatment
Juläine® (2 Vials, Same Day)

Reduced rate for a second vial on the same day.

£1590per treatment

Prices are indicative. Please book a consultation for a personalised quote.

Frequently Asked Questions

Clinical Evidence & Scientific References

Geara J, Luo L, Parlak O, Sommar P, Xu Landén N (2025): Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function

Geara J, Luo L, Parlak O, Sommar P, Xu Landén N · Journal of Biomedical Materials Research Part A, 2025PMID: 41216698

Supports: Laboratory and animal study from the Karolinska Institute in Stockholm showing that uniform poly-L-lactic acid (PLLA) microspheres, the same class of collagen biostimulator used in Juläine of Sweden, penetrate deeper into the dermis and drive fibroblast migration, extracellular matrix production and new collagen synthesis, without the inflammatory response seen with irregular PLLA microflakes.

Limitations: This is a mechanistic study in cell and animal models rather than a clinical trial in patients, so it explains how PLLA microspheres stimulate collagen but does not by itself measure cosmetic outcomes or long-term results in people.

View on PubMed

Bravo BSF et al. (2024): Exploring the Safety and Satisfaction of Patients Injected With Collagen Biostimulators: A Prospective Investigation Into Injectable Poly-L-Lactic Acid (PLLA)

Bravo BSF, Cavalcante T, Nobre CS, Bravo LG, Zafra MC, Elias MC · Journal of Cosmetic Dermatology, 2024PMID: 39663956

Supports: Prospective clinical study of 52 patients treated with an injectable PLLA collagen biostimulator and followed for 150 days, reporting that PLLA was safe and well tolerated with a low rate of adverse effects and stable patient-rated aesthetic improvement over time.

Limitations: The study used a different PLLA product (Rennova Elleva) rather than Juläine specifically, and it was a single-centre study in 52 female patients, so it supports the safety profile of PLLA biostimulators as a class rather than proving results for any one brand.

View on PubMed

*PRP London Clinic provides these references for educational purposes. Our Clinical Board regularly reviews emerging peer-reviewed literature to ensure our protocols align with the latest advancements in regenerative medicine.

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Medical Suitability Note

As a GMC-regulated practice, a mandatory consultation is required for all new patients to assess suitability and clinical need. This treatment may not be appropriate for everyone. All procedures are performed by GMC-registered doctors whose credentials can be verified on the official GMC register.