Gupta AK, Wang T, Rapaport JA (2023): Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions
Aditya K. Gupta, Tong Wang, Jeffrey A. Rapaport · Journal of Cosmetic Dermatology, 2023PMID: 37381168
Supports: Systematic review of 16 studies (15 preclinical, 1 clinical) demonstrating efficacy of exosomes derived from ADSCs and dermal papilla cells for hair restoration. Topical ADSC-exosomes showed significant increases in hair density and thickness in 39 androgenetic alopecia patients. No significant adverse reactions reported.
Limitations: Only 1 clinical study identified out of 16 total. Current clinical evidence remains limited. Further studies needed to define mechanism of action, optimise delivery and efficacy, and address long-term safety.
View on PubMed →Darwish R, Zakhary M, Wingate K, et al. (2025): From Cells to Strands: A Systematic Review Comparing Exosome Therapy, Platelet-Rich Plasma, and Minoxidil for Androgenetic Alopecia Treatment
Rajah Darwish, Marina Zakhary, Kaleigh Wingate, Noura Ayoubi, Faisal Ghafoor, Bushra Ejaz · Cureus, 2025PMID: 40821339
Supports: Systematic review comparing exosome therapy, PRP, and minoxidil for androgenetic alopecia. Exosome therapy demonstrated the most promising results for hair regrowth and safety. PRP offered moderate benefits. Exosome therapy holds the greatest potential for long-term improvement.
Limitations: Further research needed to guide clinical decision-making and optimise treatment outcomes. Minoxidil remains the most accessible treatment despite more limited effectiveness.
View on PubMed →Shah M, Dukharan V, Broughton L, et al. (2025): Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update
Milaan Shah, Victoria Dukharan, Luke Broughton, Carol Stegura, Nina Schur, Luna Samman, Todd Schlesinger · Journal of Cosmetic Dermatology, 2025PMID: 39764639
Supports: Comprehensive literature review confirming early evidence supports efficacy of exosomes for alopecia, hair rejuvenation, facial rejuvenation, hyperpigmentation, and scarring. Clinical cases demonstrated promising improvements across all indications.
Limitations: Lack of standardisation in exosome production and application protocols. Consensus on outcomes not yet established. Further investigation required to fully characterise the scope of clinical application.
View on PubMed →*PRP London Clinic provides these references for educational purposes. Our Clinical Board regularly reviews emerging peer-reviewed literature to ensure our protocols align with the latest advancements in regenerative medicine.